The Bucks were 49-33 last year and were eliminated in the first round of the playoffs by the Indiana Pacers.
The 76ers went 47-35 last season and also fell in the first round of the playoffs to the New York Knicks.
The Bucks are expected to be without Kris Middleton who has been hobbled by off-season surgery, while Philadelphia will be missing Joel Embid and Paul George.
Tip-off is set for 6:30 from Philadelphia Wednesday night.
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